The PennZone

CHADDS FORD, Pa., Feb. 13, 2025 ~ MOBILion Systems, Inc., a leading company in separation science innovation, has announced its participation in the 21st Annual US HUPO Conference. The conference will take place from February 22-26, 2025 in Philadelphia, PA. MOBILion will be showcasing its latest technology, the Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF) operating mode, through various scientific presentations. This new mode promises to increase the speed and sensitivity of LC-MS analysis for proteomics applications.

According to Melissa Sherman, Ph.D., CEO of MOBILion Systems, "Our PAMAF operating mode allows researchers to make more accurate analytical measurements and achieve deeper proteome characterization. This supports scientific discovery in critical areas of human health research." She further explains that by replacing quadrupole isolation with high-resolution ion mobility separation, PAMAF can generate fragmentation data with 10 times higher signal-to-noise ratio and 5 times faster speeds than conventional systems. With almost 100 percent ion utilization, PAMAF is particularly valuable for sample-limited workflows such as single-cell proteomics applications. MOBILion's participation at US HUPO 2025 reflects their commitment to advancing proteomics research through innovative separation science.

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During the conference, researchers will give presentations demonstrating how PAMAF's capabilities go beyond traditional LC-MS approaches. They will highlight how it reduces chimeric spectra to improve protein quantification and post-translational modification analysis. Additionally, an educational breakfast seminar will feature Prof. Birgit Schilling from The Buck Institute for Research on Aging presenting her team's research on succinylation levels in a sirtuin-5 knockout mouse model for chronic kidney disease (CKD). Using MOBILion's PAMAF mode, they were able to identify hundreds of differentially regulated succinylation sites that may contribute to phenotypic protection against kidney diseases.

The scientific program at the conference will include an oral presentation by Daniel DeBord, Ph.D., Chief Technology Officer at MOBILion, on Tuesday, February 25. The presentation, titled "Abandoning the Quadrupole for MS Fragmentation Analysis: Towards 1,000 Hz Speeds with 100% Ion Utilization Using High Resolution Ion Mobility Precursor Isolation," will be part of Session #11 - Emerging Opportunities in Proteomics from 1:40 PM to 3:00 PM. MOBILion will also have a presence in the poster sessions on Monday and Tuesday, showcasing their research on PAMAF's performance in proteomics applications.

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In addition to the scientific presentations, MOBILion is also exhibiting at booth number 18 and inviting attendees to learn more about how PAMAF is shaping the future of proteomics. The company believes that their PAMAF operating mode has the potential to revolutionize proteomics research by providing faster and more sensitive LC-MS analysis.

Overall, MOBILion's participation at US HUPO 2025 highlights their dedication to advancing proteomics research through innovative separation science. With their new PAMAF operating mode, they aim to provide researchers with a powerful tool for accurate and efficient proteome characterization. Attendees of the conference can look forward to learning more about this groundbreaking technology and its potential impact on the field of proteomics.

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